… Zinc possess several antiviral effects which are realized through the generating both innate and acquired (humoral) immune responses, facilitation of the normal functioning of innate immune system, stabilization of cell membrane inhibiting the entry of the virus, and inhibition of viral replication through interference with the viral genome transcription, protein translation, polyprotein processing, viral attachment, and uncoating. Multiple antiviral effects of Zn have been demonstrated in a variety of viral species, including several nidoviruses, for which SARS-CoV-2 belongs. It suggests that zinc supplementation may be of benefit for prophylaxis and treatment of COVID-19. Considering current absence of effective therapies for this disease, its high contagiosity, frequent life-threating course, and tremendous negative impact on the affected individuals and healthcare systems worldwide, the presented hypothesis requires urgent testing in humans.
